Comparison of postoperative analgesic effects and incidence of adverse events between sufentanil and oliceridine in patients entering AICU after surgery: a prospective, single center, randomized, double-blind, randomized parallel controlled trial

Comparison of postoperative analgesic effects and incidence of adverse events between oliceridine and sufentanil in patients entering AICU after surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400083772

Enrollment

Unknown

Registered

2024-04-30

Start date

2024-05-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative acute pain

Interventions

Oliceridine analgesic group:The Oliceridine analgesia group was treated with a 20mg/20ml Oliceridine+80ml physiological saline infusion pump. The initial loading dose was intravenous infusion of 1.6mg

Sufentanil analgesic group:The sufentanil group used a 50ug/1ml sufentanil 2 vials+98ml saline to prepare an analgesic pump. The initial loading dose was intravenous injection of 8ug, followed by a pa

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Between the ages of 18 and 75

Exclusion criteria

Exclusion criteria: Body weight35kg/m2; Pregnant or lactating women; History of opioid allergy; Diagnose or suspect sleep apnea; Treatment with chronic opioid drugs (using>15 morphine equivalent units per day for a duration of>3 days/week and a duration of>1 month within 1 year after surgery); Use any analgesics within five half-lives before surgery (48 hours if unknown); Long term use of non steroidal anti-inflammatory drugs for disease treatment (daily use for more than 2 weeks within 6 months before surgery, but if the patient uses aspirin = 325mg per day for cardiovascular disease prevention and has been treated stably for more than 30 days, it is allowed); Using drugs that may affect analgesic response (central nervous system) a- Adrenergic drugs, antiepileptic drugs, antipsychotic drugs, antidepressants or antipsychotic drugs), which have not been consistently administered for at least 30 days prior to surgery; Oral or parenteral administration of corticosteroids within 3 months prior to surgery; Or liver or kidney damage may occur during screening.

Design outcomes

Primary

Measure	Time frame
Numeric Rating Scale;Changes in levels of interleukin-6 and adrenocorticotropic hormone;	—

Secondary

Measure	Time frame
Ramsay;The incidence and severity of adverse events within two days after surgery;The number of compressions and actual effective dosage of analgesic pump;	—

Countries

China

Contacts

Public ContactBao Lang

Weifang People's Hospital

wfrmyy91@163.com+86 135 1540 0823

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026