postoperation pain
Conditions
Interventions
Treatment group (acetaminophen mannitol injection):None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who developed postoperative pain and were treated with acetaminophen and mannitol injection were selected in the retrospective cohort. Complete medical records before and after treatment were required, including demographics, past medical history, laboratory tests, concomitant medications, and adverse events. Prospective team inclusion criteria: 1. Age and gender are not limited; 2. Patients who were scheduled for elective surgery and expected to have postoperative pain and were treated with acetaminophen and mannitol injection; 3. Informed consent was obtained from patients voluntarily.
Exclusion criteria
Exclusion criteria: 1. Patients with known allergy to acetaminophen or any component of intravenous fluids; (2) patients with a history of chronic hepatitis, cirrhosis, and abnormal liver function (AST and/or ALT=2×ULN); 3. Patients deemed by the investigator to be ineligible for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of adverse events (aes) and serious adverse events (SAEs).;Total opioid consumption within 24, 48, and 72h after administration of the first study drug; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in laboratory test results;Incidence of opioid-related adverse events within 24h after the first dose;Pain intensity scores 0-24h, 24-48h, and 48-72h after the first study drug administration;Paracetamol and mannitol injection exposure, vital signs and combined medication information of patients, etc; | — |
Countries
China
Contacts
Public ContactZhang Bin
The First Affiliated Hospital of Nanchang University
Outcome results
None listed