Depression
Conditions
Interventions
Observation group:none
Control group:none
Sponsors
The First Hospital Of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Criteria for the observation group: (1) Meets the diagnostic criteria for major depressive disorder in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); (2) Untreated at the onset; (3) Ages between 18 and 50 years old; (4) Total score on the Hamilton Rating Scale for Depression (HAMD-24) > 20 points; (5) Voluntary participation in this study and signing of written informed consent. Criteria for the control group: (1) No history of psychiatric disorders; (2) HAMD-24 scores consistently less than 7 points; (3) Ages between 18 and 50 years old.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the observation group: (1) Presence of other mental disorders such as schizophrenia, anxiety disorders, etc.; (2) Presence of other physical illnesses, including cardiovascular diseases, endocrine system diseases, oral diseases, especially gastrointestinal diseases such as inflammatory bowel disease, peptic ulcer, irritable bowel syndrome, etc.; (3) Severe suicidal tendencies; (4) Evidence of alcohol or other substance dependence or abuse; (5) Family history: Family history of mood disorders, schizophrenia, and other psychiatric illnesses; (6) Treatment history: Received treatment with antibiotics, probiotics, immunosuppressants, etc., in the past month; (7) Reproductive history: Pregnant or lactating women; (8) Participation in a clinical trial in the past 90 days or participation in two or more clinical trials in the past year. The exclusion criteria for the control group are consistent with those of the observation group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Enterochromaffin cells;Gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood indicators,such as IL-1,TNF-a,CRP; | — |
Countries
China
Contacts
Public ContactLiu Penghong
The First Hospital Of Shanxi Medical University
Outcome results
None listed