Tuberculosis
Conditions
Interventions
Control group:None
Experimental group:None
Sponsors
The Third People's Hospital of Shenzhen
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? Experimental group: A. Participants aged 20-40 years; B. Initially diagnosed with female genital tuberculosis (FGTB) based on the criteria outlined in "Obstetrics and Gynecology" (9th edition, People's Medical Publishing House), considering clinical symptoms, signs, and epidemiological history (including primary infertility, sparse or absent menstruation, low-grade fever, night sweats, pelvic inflammatory disease or ascites, previous contact with tuberculosis or personal history of tuberculosis infection such as pleurisy or intestinal tuberculosis). Additionally, a positive result in any of the following tests can confirm FGTB diagnosis: a) detection of acid-fast bacilli in sputum smear or positive culture for Mycobacterium tuberculosis; b) positive GeneXpert test from endometrial or ovarian biopsy samples; c) positive PCR test combined with histopathological examination revealing typical tuberculous nodules in endometrium, fallopian tube, ovary or cervix along with uterine fallopian tube X-ray imaging for confirmation; C. No anti-tuberculosis treatment initiated. Control group: A. Participants aged 20-40 years; B. Underwent physical examination to exclude latent tuberculosis infection. ?Within 1 month, no vaginal preparations have been used; within 1 week, no cervical treatment, endometrial biopsy, intrauterine device removal or hysteroscopy has been performed; within 5 days, no vaginal irrigation has been done; and within 48 hours, no sexual intercourse has occurred; ?None of the individuals were in pregnancy or lactation, and there was no history of infertility diagnosis; ?Patients have complete clinical and pathological data, including age, body mass index (BMI), menstrual history, reproductive history, tuberculosis history, and place of residence.
Exclusion criteria
Exclusion criteria: ?Non-compliance with the current research; ?The individual has tested positive for Human Immunodeficiency Virus (HIV); ?Patients who have participated in other clinical trials of medications within the past 3 months; ?Patients with other diseases affecting the reproductive tract microbiota; ?Patients who have received antibiotic treatment within 2 months; ?Patients suffering from severe conditions such as cardiovascular, hepatic, renal disorders and others; ?Pregnant women or individuals who are planning to conceive; ?The integration of diabetes with immune-related diseases; ?Long-term use of inhibitors may lead to the use of systemic hormonal or immunotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composition of vaginal microbiota;Proportions of T cell subsets, regulatory T cells, and monocyte subsets;Levels of cytokines in the serum;Reproductive tract microecosystem; | — |
Countries
China
Contacts
Public ContactShuihua Lu
The Third People's Hospital of Shenzhen
Outcome results
None listed