Giloblastoma
Conditions
Interventions
Radiotherapy and electric field sequential group (1):None
Radiotherapy and electric field concurrent group (2):None
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
22 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. According to the WHO Classification of Central Nervous System Tumors 2021 edition, glioblastoma was histologically confirmed, IDH 1/2 wild type, and MGMT promoter region was not methylated. 2. Age 22 and above. 3. Maximum possible excision, including total or partial excision. 4. Those have received stupp regimen plus electric field therapy after surgery. 5. KPS =70. 6. Expected survival =3 months. 7. Women of childbearing age must use contraception. 8. All patients must understand and sign informed consent before entering the study. 9. Concurrent chemoradiotherapy should be initiated no later than the 8th week after surgery. 10. Can complete magnetic resonance (MR) examination.
Exclusion criteria
Exclusion criteria: 1. The tumor is located in the infratentorial or leptomeninge invasion. 2. Participated in other clinical trials. 3. During pregnancy or lactation. 4. Evidence of intracranial hypertension: midline displacement > 5mm, optic nerve papilledema, malignant vomiting, reduced level of consciousness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progress Free Survival;Recurrence free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall suvival;Recurrence pattern; | — |
Countries
China
Contacts
Public ContactShen Guoping
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed