Childhood asthma
Conditions
Interventions
asthma group 1 (Part 1):Asthma basic drug treatment and aerobic exercise
asthma group 2 (Part 1):Asthma basic drug treatment
group HMGB1-WT (Part 3):Cell transfection
group HMGB1-MUT (Part 3):Cell transfection
group mimic-NC (Part 3):Cell transfection
group let-7e-5p-mimic (Part 3):Cell transfection
group inhibitor-NC (Part 3):Cell transfection
group let-7e-5p-inhibitor (Part 3):Cell transfection
group TP73-AS1-WT (Part 3):Cell transfection
group TP73-AS1-MUT (Part 3):Cell transfection
group OE-NC (Part 3):Cell transfection
group OE-TP73-AS1 (Part 3):Cell transfection
group si-NC (Part 3):Cell transfection
group si-TP73-AS1 (Part 3):Cell transfection
group OE-TP73-AS1+mimic-NC (Part 3):Cell transfection
group OE-TP73-AS1+let-7e-5p-mimic (Part 3):Cell transfection
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
6 Years to 11 Years
Inclusion criteria
Inclusion criteria: ? The diagnostic criteria for children with bronchial asthma refer to the Recommendations for the Standardized Diagnosis and Treatment of Bronchial Asthma ,which formulated by the study group called the Pediatrics Branch of the Chinese Medical Association in 2020; ? Age 6-11 years old; ? homology in the non-acute stage of asthma attack; ? no exercise rehabilitation training before joining the group; ? There was no significant difference in age , sex and BMI between normal control group and asthma group.
Exclusion criteria
Exclusion criteria: ? Pulmonary infection, emphysema, heart failure and other complications; ? Combination of JIA and HSP, SLE, nephrotic syndrome and other autoimmune diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HMGB1;RAGE;miRNA-let-7e-5p;lncRNA-TP73-AS1;Lung function; | — |
Countries
China
Contacts
Public ContactDengna ZHU
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed