IgA nephropathy
Conditions
Interventions
Test group:If the 24-hour urine protein quantification does not exceed 50mg/(kg/d) If the renal pathology only shows moderate or below mesangial hyperplasia, and there are no relevant contraindication
Primary IgA nephropathy with crescent formation was treated with high-dose methylprednisolone pulse therapy once (15-30mg/kg per day, for 3 days, with a maximum daily dose not exceeding 0.5g) in addit
Sponsors
the First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as primary IgA nephropathy through renal biopsy. 2. Age greater than 3 years old, less than 18 years old, and weight greater than 10kg. 3. Voluntarily participate in this study and sign an informed consent form. Children under the age of 18 shall be signed by their guardians. 4. eGFR = 90ml/min/1.73m2.
Exclusion criteria
Exclusion criteria: 1. Rapidly progressive glomerulonephritis or renal pathological diagnosis of crescentic glomerulonephritis; 2. People infected with HIV, hepatitis B, hepatitis C and tuberculosis; Individuals with a history of organ transplantation or hematopoietic stem cell transplantation; 3. Individuals with epilepsy, hearing and visual impairments; 4. Patients who refuse to cooperate with clinical research; 5. Other reasons leading the researcher to believe that it is not suitable to participate in this study; 6. Combined liver dysfunction: aspartate aminotransferase (AST) = 2 times the upper limit of normal or alanine aminotransferase (ALT) = 2 times the upper limit of normal; 7. Patients who are allergic to the ingredients or any excipients in this product.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary protein quantification;Frequency of 50% reduction in urine protein;Rate of change in urine protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| eGFR;Disappearance of bloody urine; | — |
Countries
China
Contacts
Public ContactZhang jianjiang
the First Affiliated Hospital of Zhengzhou University
Outcome results
None listed