Knee Osteoarthritis
Conditions
Interventions
Combination Therapy Group:Sanwei joint paste combined with Celebrex was used for external application
Topical Chinese medicine group:Sanwei joint paste was applied externally
Oral NSAIDs:Celebrex was given orally
Sponsors
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: ? The patients met the diagnostic criteria of western medicine and the syndrome differentiation criteria of traditional Chinese medicine for knee osteoarthritis, and were unilateral. ? Age 50-75 years old; ?4 =VAS score < 8 points ? If K-L grade was ?-?, the X-ray grade was referred to K-L imaging grading method. ? voluntarily participate and sign the informed consent form, and cooperate with the follow-up.
Exclusion criteria
Exclusion criteria: ? Swollen and hot knees. ? metabolic bone disease, serious cardiovascular disease, gastrointestinal disease and other serious diseases. (3) pregnant, preparing to become pregnant, or lactating women, and mentally ill patients. ? patients with knee trauma or surgery in the past 6 months. And ? patients who were allergic to any component of the study drug Sanwei joint paste. ? patients with skin damage or skin diseases at the drug application site. ? Patients who could not take the prescribed medication and receive the treatment, poor compliance, unable to judge the efficacy or incomplete treatment, which affected the efficacy and safety judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS;Duration of pain relief;Time to disappearance of pain;Response rate for pain symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical effective rate;TCM syndrome score;Western Ontario and McMaster Osteoarthritis Index;Depth of knee joint effusion;Synovial depth of the knee joint;Knee range of motion;Tenderness thresholds around the knee joint;Assessment of gait;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactPing Wang
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed