Heart failure with preserved ejection fraction
Conditions
Interventions
Exposure group (Drug and EECP treatment ):NA
Control group (Drug treatment):NA
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age between 20 and 80 years old; (2) Patients with CHD and HFpEF(LVEF =50% and cardiac diastolic dysfunction), and CAG result shows moderate to severe stenosis; (3) Cardiac function: II~III(NYHA); (4) Exercise ability: exercise time can reach over 3 minutes, and is only limited by heart failure symptoms; (5) Clinical symptoms are stable; (6) Informed consent has been signed before participating in the study. Control group Select HFpEF patients with concomitant coronary heart disease who meet the inclusion criteria during the same period.
Exclusion criteria
Exclusion criteria: (1) Moderate to severe peripheral edema; (2) ACS diagnosed within 2 weeks before participating in the study; (3) Patients have been performed CABG or PCI within 1 week before participating in the study; (4) Contraindications of EECP : (1) severe arrhythmias interfering with EECP device triggering; (2) various bleeding disorders or bleeding tendencies; (3) active thrombophlebitis; (4) decompensated heart failure (central venous pressure > 12mmHg with pulmonary edema); (5)Severe pulmonary hypertension (mean pulmonary arterial pressure > 50mmHg) ;(6) severe aortic insufficiency;(7) deep venous thrombosis of the lower extremity;(8) aortic aneurysm requiring surgical intervention; (9) pregnant women; (10) recent cardiac catheterization (within 2 weeks). Others include arrhythmia, cardiomegaly, hypertrophic cardiomyopathy, and uncontrolled hypertension (SBP=180 mmHg, DBP=110 mmHg); (5) Cognitive and psychiatric disorders affecting clinical data collection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six-minute walking distance;Readmission Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac function;NT-proBNP;Cardiovascular events; | — |
Countries
China
Contacts
Public ContactLiu Chen
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed