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To study the brain network regulatory effector mechanism of acupuncture intervention in chronic pain of knee osteoarthritis based on fMRI study

To study the brain network regulatory effector mechanism of acupuncture intervention in chronic pain of knee osteoarthritis based on fMRI study

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083695
Enrollment
Unknown
Registered
2024-04-30
Start date
2024-05-01
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

Acupuncture group:needle acupuncture
Sham acupuncture group:Needle shallow stab non-point

Sponsors

Shandong University of Traditional Chinese Medicine Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Refer to the 1995 American College of Rheumatology guidelines. Include patients aged 40-70 with a disease duration of more than 6 months, Kellgren-Lawrence radiographic grade of II or III, and a Numerical Rating Scale (NRS) pain score of at least 4. Right-handed patients only.

Exclusion criteria

Exclusion criteria: (1) Having a history of knee surgery or waiting for knee surgery (knee replacement or knee arthroscopic surgery); (2) Evaluate a history of arthroscopy examination within 1 year and a history of intra-articular injection in the past 6 months for the joint; (3) Knee pain caused by other diseases (such as joint dissociation, severe joint effusion, infection, malignant tumors, autoimmune diseases, trauma, fractures, gout, etc.); (4) Severe acute or chronic organic or psychiatric diseases; (5) Coagulation dysfunction diseases (such as hemophilia); (6) Pregnant, pregnant, and lactating women; (7) Individuals with claustrophobia or those who carry pacemakers, metal products, or other contraindications for MRI examination; (8) Those with clear organic lesions or severe head anatomical asymmetry found in MRI scans; (9) Received massage or acupuncture and moxibustion treatment in the past 1 month; (10) Individuals who are allergic to needles and alcohol, or are afraid of puncturing; (11) Participate in other clinical researchers within the past 3 months.

Design outcomes

Primary

MeasureTime frame
NRS;Functional magnetic resonance evaluation index;

Secondary

MeasureTime frame
WOMAC;STAI;

Countries

China

Contacts

Public ContactHao Mingyao

Shandong University of Traditional Chinese Medicine Affiliated Hospital

haomingyao@yeah.net+86 139 5311 0926

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026