liver cirrhosis
Conditions
Interventions
Carvedilol alternate day administration group:Carvedilol alternate day administration
Continuous administration of carvedilol group:Continuous daily administration of carvedilol
Sponsors
Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Clinical manifestations, laboratory tests, imaging examinations, or liver biopsy confirm liver cirrhosis; 2. HVPG measurement before grouping and HVPG>12mmHg; 3. Endoscopic confirmation of esophageal and gastric varicose veins; 4. Age range from 18 to 75 years old; 5. Patients and their families agree on preoperative and postoperative follow-up items
Exclusion criteria
Exclusion criteria: 1. Age greater than 75 years old; 2. Late stage liver cancer (= BCLC stage C) or other malignant diseases; 3. Portal hypertension caused by pre - or post hepatic factors; 4. Child Pugh score>14 points or MELD score>30 points; 5. Contraindications to NSBB; 6. History of previous TIPS surgery and splenectomy surgery; 7. Concomitant severe heart, lung, and kidney diseases; 8. The researcher believes that it is not suitable to participate in this study
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Rate of first or second bleeding;Mean arterial blood pressure;Heart rate; | — |
Primary
| Measure | Time frame |
|---|---|
| hepatic venous pressure gradient(HVPG); | — |
Countries
China
Contacts
Public ContactChunqing Zhang
Department of Gastroenterology, East Campus of Shandong Provincial Hospital
Outcome results
None listed