Migraine
Conditions
Interventions
Group of migraine patients transformed to chronic debilitating migraine:Study Part 1: Acute Pain Management for Migraine
Study Part 2: Migraine Preventive Treatment + Alternative Migraine Acute Pain R
Group of migraine patients with indications for preventive treatment :Study Part 1: Migraine preventive treatment + migraine acute analgesic treatment
Study Part 1: Migraine preventive treatment + migraine acute analgesic treatment
Acute Pain Management Group:Study Part 1: Acute analgesic treatment of migraine
Study Part 2: Acute analgesic treatment of migraine
Study Part 3: Acute Pain Management for Migraine
Sponsors
The First affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Part 1 : The establishment of a clinical cohort and biobank for migraine 1) Age 18-60, right-handed; 2) Meeting the diagnostic criteria for EM or CM as stipulated in the 3rd edition of the International Classification of Headache Disorders; 3) Duration of headache in the patient is greater than 1 year; 4) The patient and/or their legal representative understand and comply with the study procedures and methods, voluntarily participate in this trial, and sign the informed consent form in writing; 5) The subjects are able to read, understand, and complete the research questionnaire and headache diary. Part 2: Multidimensional Features and Clinical Management Status of Migraine Chronic Transformation in the Real World Based on the cohort established in Part 1, the following patients will be included: 1) Patients with migraine who meet the criteria for preventive treatment, such as having at least 2 migraine attacks per month, ineffective or intolerable acute treatment. 2) Patients with migraine chronic transformation, those who experience a transition from episodic migraine to chronic migraine during the follow-up period. Part 3: Establishment and Promotion of Causal Machine Learning Models for Migraine Chronic Transformation Early Warning and Early Intervention Selection Patient inclusion criteria are the same as in Part 2.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1) Patients with psychiatric disorders, suicidal tendencies, or severe cognitive impairments. 2) Patients who cannot cooperate with follow-up, record headache diaries, or refuse to participate in the study. 3) Patients who refuse to sign the informed consent form. Parts 2 and 3 are conducted based on Part 1. Additional exclusion criteria for patients undergoing MRI scans: 1) Use of prophylactic headache treatment medications in the past month. 2) Consumption of analgesics, sedatives, sleeping pills, coffee, alcohol, or other drugs affecting mental status within 12 hours before the scan. 3) Presence of other types of chronic pain or sensory abnormalities, history of head injuries, cranial surgery, or severe mental disorders. 4) History of systemic diseases requiring long-term medication, such as hypertension, diabetes, coronary atherosclerotic heart disease, or cerebrovascular diseases. 5) Situations where undergoing MRI scans would pose risks to the patients, such as the presence of cardiac pacemakers, artificial metallic heart valves, cochlear implants, various drug pumps, metal objects, intracranial aneurysm clips, coronary stents, various intravascular stents and filters, various artificial joints and prostheses, metal fixation devices, dentures, metal-ceramic teeth, orthodontic braces, etc. 6) Pregnancy or lactation. 7) Claustrophobia. 8) Patients with abnormal findings in cranial imaging studies (e.g., severe ischemic lesions, cysts, etc.). 9) Other situations that are not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part 1-3:Migraine days per month; | — |
Secondary
| Measure | Time frame |
|---|---|
| Part 1&2:Migraine Disability Assessment,MIDAS;Part 1&2:Headache Impact Test,HIT-6; | — |
Countries
China
Contacts
Public ContactJiying Zhou
The First affiliated Hospital of Chongqing Medical University
Outcome results
None listed