Major depressive disorder
Conditions
Interventions
EP:Esketamine + Propofol
EC:Esketamine + Ciprofol
NP:Normal saline + Propofol
NC:Normal saline + Ciprofol
Sponsors
Renmin hospital of Wuhan university
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: An independent investigator is responsible for recruiting subjects undergoing MECT. To be eligible, subjects have to be male or female, 14 to 65 years; meet The diagnostic and statistical manual of mental disorders-5 criteria for MDD; without psychotic features, confirmed by the Mini-International Neuropsychiatric Interview; American Society of Anesthesiologists (ASA) physical status class I or ?; schedule for MECT; sign informed consent for participation.
Exclusion criteria
Exclusion criteria: The key exclusion criteria include coexisted diagnosis of other psychotic disorder or nervous system diseases; be allergic or contraindicatic to study medications or any of their formulation ingredients; a recent history (past 6 months) of drug or alcohol abuse; pregnancy or lactation; refusal for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total scores of HADM-24; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of response and remission;The incidence of adverse events;The details of anesthesia;The details of ECT; | — |
Countries
China
Contacts
Public ContactQingtao Meng
Renmin hospital of Wuhan university
Outcome results
None listed