epileptic encephalopathy
Conditions
Interventions
test group:High-Definition Transcranial Electrical Stimulation
Sponsors
Shenzhen Children's Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 3 Years
Inclusion criteria
Inclusion criteria: (1) between 1 and 3 years of age, (2) meeting the criteria for EE diagnosis, (3) complete clinical data, (4) insufficient response to the combination of two or more antiepileptic drugs, (5) seizure frequency= 1 time/week, (6) no change in anticonvulsant medication during tACS intervention. Diagnostic criteria for epileptic encephalopathy: (1) Two clinical episodes (at least 24 hours apart) of unprovoked seizures; (2) early age of onset; (3) Obvious abnormality of electroencephalography; (4) progressive neuropsychiatric dysfunction or degeneration; (5) or meet the following diagnostic criteria for epilepsy syndromes: 1)IS: Serial seizures, EEG between episodes shows typical high arrhythmia or variant high arrhythmia, often accompanied by psychomotor retardation or regression, and normal development before the onset of the disease. 2) OS: tonic and spasmodic seizures in early infancy, EEG burst inhibition pattern, severe psychomotor disorders. 3) DS: onset within 1 year of age, the first episode is mostly febrile seizures; within 1 year of age, the main manifestations are fever-induced generalized or hemiclonic convulsions of a long duration, after 1 year of age, various forms of athermic convulsions gradually appear, and the seizures are often heat-sensitive; early development is normal, after 1 year of age, intellectual and motor development is delayed or regressed, ataxia and pyramidal signs may appear; EEG is often not abnormal before 1 year of age, and after 1 year of age, generalized spinous slow waves, multispinous slow waves or focal, Multifocal epileptiform discharge. 4) LGS: multiple types of seizures, generalized slow (1.5-2.5Hz) spike-slow complex wave on EEG, mental retardation. 5) EME: segmental, migratory myoclonus from the first day to the first few weeks after birth, EEG burst inhibition pattern, psychomotor retardation. 6) ECSWS: electroencephalogram (EEG) slow-wave electro-continuous during sleep, various types of seizures, neuropsychological and motor behavior disorders.
Exclusion criteria
Exclusion criteria: (1) Symptomatic epilepsy caused by tumors, trauma, infection, and focal cortical dysplasia was excluded;(2) Anticonvulsant drug therapy was effective;(3) Seizure frequency<1 seizure/week;(4) Changes in anticonvulsant medication during tACS intervention; (5) Refusal of parents to participate in clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure frequency;Mental development; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the number of spikes and EEG background in patients with interictal EEG; | — |
Countries
China
Contacts
Public ContactDezhi Cao
Shenzhen Children's Hospital
Outcome results
None listed