Vascular aging
Conditions
Interventions
Test group :Guilingji capsule: oral, once 0.6g (2 capsules), once, 2 hours before breakfast with light saline delivery, continuous oral administration for 24 weeks
Control group :Comfort capsule: oral, once 0.6g , once, 2 hours before breakfast with light salt water delivery, continuous oral administration for 24 weeks
Sponsors
Tongji Hospital Affiliated to Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 45-75 years (including boundary value, male and female); 2. Survival time = 6 months; 3. Brachial ankle pulse wave velocity (baPWV) = 1400cm / s; 4. In line with the TCM spleen and kidney deficiency diagnosis; 5. No comprehension, hearing or visual impairments, can perform general commands, communicate normally and complete physical assessment tests; 6. Patients who signed an informed consent form after informed consent and volunteered to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Acute or serious malignancy with serious chronic diseases of the elderly, such as acute exacerbations of COPD, acute coronary artery disease, Parkinson's disease, depression, pulmonary tuberculosis (other than old tuberculosis), malignancy and cachexia; 2. Antihypertensive drugs such as angiotensin converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, and aldosterone antagonists, statins, and prostaglandins (such as oral preparations of beprostaglandin sodium) were taken within the last 1 month; 3. The heart function of the New York Heart Disease Association (NYHA) score was grade III to IV; 4. Previously diagnosed with diabetes mellitus; 5. Impaired liver and kidney function, in which ALT and / or AST > 2.0 times the upper limit of normal; Scr > 1.2 times the upper limit of normal value; 6. Patients with serious skeletal muscle disease (eg, osteomyelitis, osteonecrosis of the femoral head, myasthenia gravis, peripheral paralysis, etc.) 7. Those who have taken Traditional Chinese Medicine Patent Prescription, Chinese Medicine, Vitamin D, Vitamin K and hormone; 8. Those who are completely bedridden or have difficulty moving; 9. Allergy or allergy to known ingredients in this medicine; 10. Female subjects who are pregnant, lactating, or plan to become pregnant during participation in the trial; 11. Participants in other intervention trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BaPWV; | — |
Secondary
| Measure | Time frame |
|---|---|
| BaPWV;Carotid ultrasonic IMT thickness ;Vasodilatory function ;blood pressure ;Standard Scale of Fried Debilitating Syndrome ;Simple Intelligence Scale Score ;Ability of daily living scale score ;TCM Syndrome Scale Score ;Insomnia severity index;Pittsburgh Sleep Quality Index ; | — |
Countries
China
Contacts
Public ContactCuntai Zhang
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed