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Effects of resistance training combined with vibration training on the IGF-1/PI3K/AKT/FOXO3 axis in a population with sarcopenia

Effects of resistance training combined with vibration training on the IGF-1/PI3K/AKT/FOXO3 axis in a population with sarcopenia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083643
Enrollment
Unknown
Registered
2024-04-29
Start date
2024-04-30
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sarcopenia

Interventions

Control group:The subjects in the control group will receive a 60-min education course two times a month at the community center.
Resistance training group(RT group):The resistance training group(RT group) will participate in a 12-week resistance exercise programme three times per week.
Vibration training group(VT group):The vibration training group(VT group) will receive Whole Body Vibration Training (WBVT) for 20 minutes three times per week for 12 weeks.
Resistance training and vibration training group(RVT group):The Resistance and vibration training group (RVT group) will receive 12 weeks of resistance vibration training three times per week. At the

Sponsors

Chengdu Sport University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria are elder adults between the ages of 65 and 80 years with a diagnosis of sarcopenia according to the AWGS 2019 criteria, as well as the absence of serious medical conditions such as uncontrolled hypertension, hyperlipidaemia, hyperglycaemia, and diabetes mellitus, and the absence of untreated medical conditions such as gallstones or renal stones, as well as infectious diseases, and the participants don’t have a regular exercise routine for more than 3 months.

Exclusion criteria

Exclusion criteria: Exclusion criteria are the subjects with pathological bone diseases, chronic inflammatory conditions such as rheumatoid arthritis, neurological problems affecting gait speed, receiving regular guided exercises more than three times per week, chairbound or bed- bound and not able to stand on vibration platform, with cardiovascular concern such as with pacemaker in situ or malignancy and with acute fractures or severe osteoarthritis.

Design outcomes

Primary

MeasureTime frame
IGF-1 concentrations;PI3K signalling pathway;AKT signalling pathway;FOXO3 protein activity;Skeletal muscle mass;

Secondary

MeasureTime frame
Handgrip strength;Gait speed;36-item Short-Form Health Survey;Time-up-and-go test;

Countries

China

Contacts

Public ContactHaoyang Zhou

Chengdu Sport University

zharry@163.com+86 137 8173 6425

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026