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Clinical effects and mechanisms of acupuncture combined with transcranial magnetic stimulation in the intervention of upper limb spasticity after stroke based on the "cortical-reticular-spinal" pathway

Clinical effects and mechanisms of acupuncture combined with transcranial magnetic stimulation in the intervention of upper limb spasticity after stroke based on the "cortical-reticular-spinal" pathway

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083631
Enrollment
Unknown
Registered
2024-04-29
Start date
2023-11-16
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spasticity of upper limbs after stroke

Interventions

treatment group:Drug therapy + routine rehabilitation therapy + acupuncture + transcranial magnetic stimulation(cTBS)
control group:Drug therapy + routine rehabilitation therapy + acupuncture + sham transcranial magnetic stimulation (sham cTBS)

Sponsors

The First Teaching Hospital of Tianjin University of TCM
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? Meet the diagnostic criteria of Chinese and Western medicine, first unilateral stroke confirmed by MRI or CT, or previous history of lacunar cerebral infarction without sequelae. ? Aged between 18-80 years old. ? Being in the post-stroke period. ? MAS score 1-3, Brunnstrom II-I?. ?Measured Mental State Examination (MMSE) score >23, good compliance with interventions. ? Signed informed consent.

Exclusion criteria

Exclusion criteria: ? More than 1 stroke (patients with previous transient ischemic attack may be involved), bilateral cerebral hemispheric lesions. ? Those with epileptic seizures or a history of epileptic seizures after stroke, severe skull fracture or cranial defects. ? Those with significant auditory comprehension disorders after stroke. ? Those who have intracranial implants, pacemakers or implanted drug pumps in their body. ?Pregnant or breastfeeding women. ?Serious injury of heart, lung, liver, kidney and other organs that cannot tolerate the training. ? Participation in other spastic rehabilitation studies.

Design outcomes

Primary

MeasureTime frame
modified Ashworth scale (MAS);ß value of functional Near-Infrared Spectroscopy (fNIRS);—

Secondary

MeasureTime frame
Fugl-Meyer Assessment-Upper Extremity (FMA-UE);Modified Barthel Index (MBI);F-wave amplitude;F-wave conduction velocity;F-wave latency;F-wave occurrence;F/M amplitude ratio;fractional anisotropy (FA) for Diffusion Tensor Imaging (DTI);—

Countries

China

Contacts

Public ContactYu Tao

The First Teaching Hospital of Tianjin University of TCM

doctoryutao@163.com+86 139 2099 9215

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026