intrahepatic cholestasis of pregnancy, ICP
Conditions
Interventions
control group:None
Study group:none
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? The diagnostic criteria for ICP refer to the "Guidelines for the Diagnosis and Treatment of Intrahepatic Cholestasis of Pregnancy (2015)"; ? Primiparas or multiparas aged between 18 and 40 years old; ? Singleton pregnancy; ? Those who have not received ICP drug treatment during the collection of biological samples between the 28th and 34th weeks of pregnancy. Inclusion criteria for the 60 control group: singleton healthy pregnant women matched in a 1:1 ratio based on the age and gestational weeks of ICP patients (with no comorbid medical or surgical diseases and pregnancy
Exclusion criteria
Exclusion criteria: ? Multiple pregnancies; ? History of hepatobiliary and other digestive system diseases, or history of other liver damage; ? History of hypertension, diabetes, hyperthyroidism, rheumatic diseases, mental illness, other autoimmune diseases, and endocrine and metabolic diseases; ? Long-term use of antibiotics, immunosuppressive agents, and other drugs during pregnancy; ? History of blood transfusion, organ transplantation or immunotherapy; ? Not willing to participate in this study, or not willing to provide stool and blood samples for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bile acids ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function; | — |
Countries
China
Contacts
Public ContactZhenyan Han
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed