Atrophic Acne Scars
Conditions
Interventions
Test group (fractional CO2 laser + extracellular vesicles of MSCs loaded aloe vera hydrogel):Patients receive fractional CO2 laser therapy every 4 weeks. Extracellular loaded aloe vera hydrogel will b
Control group 1 (fractional CO2 laser + aloe vera hydrogel):Patients receive fractional CO2 laser therapy every 4 weeks. Aloe vera hydrogel will be applied on the face every 3 days after each fraction
Control group 2 (fractional CO2 laser + hydrogel):Patients receive fractional CO2 laser therapy every 4 weeks. Hydrogel will be applied on the face every 3 days after each fractional CO2 laser therapy
Sponsors
South China Hospital of Shenzhen University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) 18 to 45 years old, without restriction of gender; (2) Diagnosed with facial atrophic acne scar; (3) Duration: 3 months to 10 years; (4) The patients could comply to the treatments and follow up schedule, without any other treatment for atrophic acne scar during the survey; (5) Informed consent should be signed.
Exclusion criteria
Exclusion criteria: (1) Photo sensitive skin or have taken photo sensitive medications within 1 month; (2) Exposure to sunlight within 1 month or might be exposed to sunlight within 1 month after treatments; (3) Have received facial tretinoin treatment, micro-invasive therapy, filler therapy, cosmetic surgery, ultraviolet therapy, intense pulse light therapy, laser treatment or radiofrequency treatment within 1 month; (4) Suffered from skin infection, wounds or insections that have not recovered; (5) Patients who were susceptible to hypertrophic scars or keloids; (6) Women who were pregnant or lactating; (7) Patients who were suffered from heart failure, renal failure, liver failure, or other severe fundamental diseases; (8) Patients who were suffered from immune deficiency or had suffered from cancer; (9) Patients suffered from psychological diseases or have unrealistic expectancy about treatment outcome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VISIA skin analysis;Scar cosmesis assessment and rating, SCAR;Physiologic characteristics of skin;Scar types;DLQI (Dermatology Life Quality Index);ECCA grading scale;Global Aesthetic Improvement Scale (GAIS);Thrombin Time (TT) Test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Semi-quantitative assessment of acute inflammatory reaction; | — |
Countries
P.R. China
Contacts
Public ContactXianbiao Zou
South China Hospital of Shenzhen University
Outcome results
None listed