Acute ischemic stroke (onset<4.5 hours)
Conditions
Interventions
Case series:None
Sponsors
Linyi People's Hospital (Shandong Provincial Clinical Research Center for Geriatric Diseases)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age = 18 years old, regardless of gender; (2) mRS 0-1 before onset; (3) AIS patients treated with TNK thrombolysis (onset<4.5 hours); (4) The subject or guardian voluntarily signs an informed consent form.
Exclusion criteria
Exclusion criteria: (1) The patient refused to participate in this study or was unwilling to cooperate with a 90 day follow-up; (2) According to the judgment of the researchers, it is not suitable to participate in this study or participating in this study may lead to greater risks for the subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of symptomatic intracranial hemorrhage within 36 hours (as defined by ECASSIII);90 day mRS score 0-1 points ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of significant bleeding events in other areas within 90 days (as defined by GUSTO bleeding) ;90 day overall mortality rate ;Incidence rate of adverse events/serious adverse events within 90 days;Proportion of subjects with mRS0-2 scores at 90 ± 7 days;90 ± 7 day mRS level distribution;24-36 hours, 7 ± 1 days, or before discharge (whichever occurs first), NIHSS score 0-1 or improvement from baseline, the proportion of subjects with a NIHSS score of = 4;90 ± 7 days of health-related quality of life (EQ-5D);The proportion of subjects with a Bathel index = 95 points within 90 ± 7 days; | — |
Countries
China
Contacts
Public ContactZiRan Wang
Linyi People's Hospital
Outcome results
None listed