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Observation of preoperative analgesic effect of bupivacaine liposomes on the pericapsular nerve group block without opioid drugs in elderly patients with hip fractures: A single center, prospective, randomized controlled Study

Observation of preoperative analgesic effect of bupivacaine liposomes on the pericapsular nerve group block without opioid drugs in elderly patients with hip fractures: A single center, prospective, randomized controlled Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083591
Enrollment
Unknown
Registered
2024-04-29
Start date
2024-05-01
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preoperative analgesia for hip fracture

Interventions

Group C:After admission, relevant contraindications were excluded and PCIA analgesia was used. The formula was 2ug/kg sufentanil+10mg tropisetron, diluted with physiological saline to 100ml, with a ba
Group B:Perform ultrasound guided PENG block, using local anesthetic: 15ml of bupivacaine liposome+ 5ml of 0.9% NS, with a total amount of 20ml. After observing for 0.5 hours to confirm no adverse rea

Sponsors

Fujian provincial hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Patients with hip fractures (femoral neck fractures, intertrochanteric fractures) who plan to undergo surgical treatment; 2) Individuals aged = 65 years old, regardless of gender; 3) Body mass index (BMI) 18.5-30 kg/m2; 4) Patients with a VAS score of = 4 for exercise; 5) The American Society of Anesthesiologists (ASA) is classified as Grade I-III; 6) Voluntarily sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1) Those who do not understand or refuse to participate in the experiment; 2) Individuals who are allergic to bupivacaine and bupivacaine liposomes; 3) Those who have used pain medication within 24 hours before surgery; 4) Patient's VAS score for exercise is less than 4 points; 5) Individuals with contraindications to PENG blocks, NSAIDs, and opioid drugs; 6) After admission, all patients were evaluated for their basic cognitive function using the Mini Mental State Examination (MMSE) (with a maximum score of 30, scores ranging from 27 to 30 indicating normal, and scores less than 27 indicating cognitive impairment). Patients with MMSE scores less than 24 were evaluated; 7) Infection at the puncture site or inability to distinguish anatomical structures or determine surface positioning points under ultrasound; 8) History of peripheral neuropathy; 9) Coagulation dysfunction; 10) After completing the basic laboratory examination, the anesthesiologist of the anesthesia research group will evaluate those who have contraindications to surgical anesthesia.

Design outcomes

Primary

MeasureTime frame
Resting and exercise pain scores;Quadriceps muscle strength;

Secondary

MeasureTime frame
Cycle indicators;Use of analgesic drugs;Sleep quality score;The time from injury to surgery;The time from surgery to discharge;Hospitalization days;Medical expense;Complications;

Countries

China

Contacts

Public ContactXiaochun Zheng

Fujian provincial hospital

zhengxc2@163.com+86 137 0505 8351

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026