recurrent implantation failure in frozen embryo transfer cycles
Conditions
Interventions
experimental group:luteal support therapy+ LMWH
control group:luteal support therapy
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: (1) Age = 40 years when the oocytes were retrieved (2) Planning for FET after IVF or ICSI cycles (3) The participants have at least one good-quality frozen blastocyst and will transfer only one frozen blastocyst. The blastocyst should be from day 5 or day 6 and have a Gardner morphology score = 4 BC. (4) Participants with a history of at least 3 failed fresh/frozen high-quality embryo transfer cycles . (5) Participants are willing to cooperate with the research plan and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) One of the couples has chromosomal abnormalities. (2) Untreated submucosal uterine fibroids or endometrial polyps (3) History of autoimmune diseases, eg antiphospholipid syndrome (APS), Sjogren's syndrome (SS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and so on. (4) Thin endometrium (< 7 mm) before transfer (5) Medical contraindications to LMWH or ART and/or pregnancy (6) Women who are currently receiving any anticoagulant drugs, such as aspirin. (7) History of intrauterine adhesions (8) Untreated hydrosalpinx visible via ultrasound (9) Embryos planned for thawing and transfer are from cryopreserved oocyte sources or have undergone secondary cryopreservation (10) History of recurrent spontaneous abortion (RSA) (11) FET after preimplantation genetic testing(PGT)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate;biochemical pregnancy rate;embryo implantation rate;early miscarriage rate;ongoing pregnancy rate;ectopic pregnancy rate;pregnancy-related complications;perinatal complications;fetal birth weight;congenital malformations;other adverse reactions; | — |
Countries
China
Contacts
Public ContactCui Linlin
The Second Hospital of Shandong University
Outcome results
None listed