Helicobacter pylori infection
Conditions
Interventions
The bismuth quadruple therapy group:Bismuth quadruple therapy for 14 days:esomeprazole 20mg bid(30 minutes before meals),amoxicillin 1000mg bid(30 minutes after meals),clarithromycin 500mg bid (30 min
The vonoprazan and high-dose amoxicillin dual therapy group:The vonoprazan and high-dose amoxicillin dual therapy for 14 days:vonoprazan 20mg bid(30 minutes before meals) and amoxicillin 750mg 4 times
Sponsors
Jiangsu Province Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18–85 years with a confirmed diagnosis of type 2 diabetes mellitus (according to the Standards of Care in Diabetes—2024 by the American Diabetes Association [ADA]); 2. Active Helicobacter pylori (H. pylori) infection confirmed by a positive 13C-urea breath test (13C-UBT); 3. No prior history of H. pylori eradication therapy; 4. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a known allergy or hypersensitivity to the medications used in this study; 2. Use of Vonoprazan (Vocinti), proton pump inhibitors (PPIs), H2 receptor antagonists, antibiotics, bismuth agents, or traditional Chinese medicines with antibacterial effects within 4 weeks prior to treatment; 3. History of gastrectomy or gastric malignancies; 4. Gastroduodenal ulcer with recent bleeding or signs of bleeding within the past 4 weeks; 5. Pregnant or lactating women, or patients with plans to conceive during the study period; 6. Presence of severe concomitant diseases that could affect the evaluation of this study (e.g., cardiac, pulmonary, hepatic, renal, metabolic, or psychiatric diseases, malignant tumors, etc.); 7. Difficulty in completing follow-ups or other factors that may affect compliance/adherence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood sugar control;Compliance;Incidence of Adverse Reactions; | — |
Countries
China
Contacts
Public ContactZhou Xiaoying
Jiangsu Province Hospital
Outcome results
None listed