Subclincial Depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) Age 18-35 years old; 2) BMI:18-30kg/m^2; 3) Strong willingness to participate in this study; 4) Subclinical depression as assessed by a combination of the Hamilton Clinical Interview and the Depression Self-Rating Scales (with 2 or more depressive symptoms but fewer than 5 of the DSM diagnostic criteria for depression, with a duration of at least two weeks, with impaired social functioning but not meeting the diagnostic criteria for mild depression, major depression, or dysphoric mood disorder); scores of 9-20 on the PHQ-9 Scale; BDI scores >=8; HAMD scores 7-17; 5) Normal vision and hearing (or normal after corrected), being able to understand the instructions and the contents of the research; 6) Suitable for MRI examination: (1) No metal or electronic implants in the body (such as metal cochlear implants or pacemakers); (2) No prosthesis (such as dentures, metal braces, etc.); (3) No hair dying or tattooing; (4) No claustrophobia; (5) No severe spondylosis; (6) No traumatic brain injury.
Exclusion criteria
Exclusion criteria: 1) Patients diagnosed with major depressive disorder (particularly those who are receiving antidepressants), schizoaffective disorder, schizophrenia, bipolar disorder, mental retardation, pervasive developmental disorder, delirium, dementia, memory impairment, or other cognitive disorders consistent with the diagnostic manifestations of DSM-5; 2) Individuals who showed dangerous suicidal ideation or suicide attempt behavior during the clinical interview; 3) CIn the process of a severe stressful event; 4) Have a history of addictions (including substance use disorders, internet addiction etcs.)u r
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| level of depression;depression severity;anxiety level;regulatory emotional self-efficacy;ruminative response;mindfulness;interoceptive awareness;alexithymia;loneliness;posttraumatic growth;perceived social support;sleep quality;self-compassion;PPG;motor activity (ACC/GYRO);sleep quality (sleep time);self-generated thoughts;self-esteem;self-efficacy;mental flexibility;cognitive flexibility;Attention to Positive and Negative Information;emotional attention;attentional control (subjective);cognitive control/response inhibition;sense of well-being;life satisfaction;psychological resilience;experiential avoidance;emotional working memory;MRI T1 images;Resting-state fMRI;diffusion tensor imaging;3D-T1 structural imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive emotion regulation strategies;daily moods;skin temperature;time (duration) of mobile phone use per day;number (frequency) of mobile phone use per day;number of anwersing/dialing out phone calls and length of calls per day;number of receiving/sending messages per day;number of mobile phone apps used per day;pleasure experience;childhood trauma;trait anxiety ;emotional contagion ;co-rumination ;interpersonal reactivity (empathy ability);behavioral inhibition/ activation; | — |
Countries
China
Contacts
Institute of Psychology, Chinese Academy of Sciences