hemophagocytic syndrome
Conditions
Interventions
1 groups(hemophagocytic syndrome):None
2 groups(typically developing):None
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: (1) Children diagnosed with CNS-HLH according to the 2018 guidelines of the Chinese Medical Association (2) The treatment plan for children with CNS-HLH is HLH-04 program.
Exclusion criteria
Exclusion criteria: (1) Children with other diseases (other than HLH) or confirmed head MRI abnormalities before the occurrence of this disease (HLH); (2) Children with failed sedation, poor general condition, large image noise artifacts, and unclear final diagnosis; (3) Children with no sense of autonomy, poor compliance, and in the state of ECG monitoring.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain volume data for magnetic resonance 3D-T1 sequences; | — |
Secondary
| Measure | Time frame |
|---|---|
| FA value of the magnetic resonance DTI sequence;CBV values for magnetic resonance ASL sequences;CBF values for magnetic resonance ASL sequences;The amount of iron deposition for the magnetic resonance SWI sequence;The amount of copper deposition for the magnetic resonance SWI sequence; | — |
Countries
China
Contacts
Public ContactXu Ye
Children's Hospital of Chongqing Medical University
Outcome results
None listed