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Clinical efficacy and mechanism study of Jueyin Antihypertensive Decoction (modified prescription of Chai-gui Decoction) in the treatment of Jueyin type hypertension

Clinical efficacy and mechanism study of Jueyin Antihypertensive Decoction in the treatment of Jueyin type hypertension

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083559
Enrollment
Unknown
Registered
2024-04-28
Start date
2024-04-29
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

Experimental group:Antihypertensive drugs + Jueyin Antihypertensive Decoction

Sponsors

Wuxi Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the corresponding diagnostic standards of Western medicine and traditional Chinese medicine; 2. Age between 18 and 80 years old (including boundary values); 3. Stable condition of underlying diseases; 4. Voluntarily sign an informed consent form, with high treatment compliance and the ability to follow up according to regulations.

Exclusion criteria

Exclusion criteria: 1. Secondary hypertension; 2. Diagnosed as severe arrhythmias, structural heart disease or other acute cardiac diseases such as acute stroke (acute phase) or severe pulmonary insufficiency; 3. Severe liver and kidney dysfunction (male serum creatinine>2.5mg/dl (>220umol/L), female serum creatinine>2.0mg/dl (>175umol/L); The liver function test value is 2 times higher than the upper normal limit 4. Cachexia or severe hematopoietic system diseases; 5. Having mental illness and unable to cooperate with doctors for treatment; 6. Women preparing for pregnancy, pregnancy or lactation; 7. With a history of multiple drug and food allergies and are prone to allergies to relevant traditional Chinese medicine ingredients; 8. Participated or are currently participating in other clinical trials within the past three months; 9. Other patients deemed by the researchers to be unable to participate in this trial.

Design outcomes

Primary

MeasureTime frame
Blood pressure;Scores of traditional Chinese Medicine syndromes ;

Secondary

MeasureTime frame
Serum metabolites;sCD36;ET-1;Ang?;RGS2;iPLA2;

Countries

China

Contacts

Public ContactXu Yifan

Wuxi Hospital of Traditional Chinese Medicine

20221638@njucm.edu.cn+86 156 0151 9297

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026