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Research on the mechanism and transformation of CD8+T cell depletion in the immune microenvironment of malignant tumors by B7-H4

Research on the mechanism and transformation of CD8+T cell depletion in the immune microenvironment of malignant tumors by B7-H4

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400083555
Enrollment
Unknown
Registered
2024-04-28
Start date
2024-05-01
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glioma

Interventions

Glioma patients (prospective section):None
Pan tumor species (retrospective section):None

Sponsors

Huashan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Prospective collection of biological samples and clinical information from glioma patients Inclusion Criteria Patients with brain tumors admitted to the Neurosurgery Department of Huashan Hospital affiliated with Fudan University can be enrolled if they meet the following conditions: 1) Age greater than 18 years old, regardless of gender; 2) Preoperative imaging suspected glioma; 3) Surgery is required; 4) The pathological report of intraoperative frozen section showed glioma; 5) On the basis of ensuring that it does not affect the clinical routine diagnosis and treatment needs, a certain amount of fresh biological samples can be taken for research; 6) Voluntarily sign an informed consent form. Retrospective collection of biological samples and clinical information of glioma, breast cancer, thyroid cancer, lung cancer, colon cancer, liver cancer, bladder cancer, prostate cancer and gastric cancer Inclusion Criteria All cases of glioma, breast cancer, thyroid cancer, lung cancer, bowel cancer, liver cancer, bladder cancer, prostate cancer and stomach cancer diagnosed by the Department of Pathology of Huashan Hospital affiliated to Fudan University can be included in the group if they meet the following conditions: 1) Age greater than 18 years old, regardless of gender; 2) Pathological diagnosis: glioma, breast cancer, thyroid cancer, lung cancer, colon cancer, liver cancer, bladder cancer, prostate cancer or stomach cancer; 3) On the basis of ensuring that it does not affect clinical routine diagnosis, paraffin sections (5 pieces) can be taken for immunohistochemical staining; 4) The patient voluntarily joined this study.

Exclusion criteria

Exclusion criteria: Prospective collection of biological samples and clinical information from glioma patients Exclusion criteria If a patient meets any of the following criteria, they will not be eligible for inclusion in this study: 1) The pathological results of intraoperative frozen sections do not match those of gliomas; 2) After removing the samples required for normal diagnosis and treatment, the remaining sample size is not enough for research; 3) The patient is unwilling to join the study. Retrospective collection of biological samples and clinical information of glioma, breast cancer, thyroid cancer, lung cancer, colon cancer, liver cancer, bladder cancer, prostate cancer and gastric cancer Exclusion criteria If a patient meets any of the following criteria, they will not be eligible for inclusion in this study: 1) Those who have stored wax blocks for too long and become moldy; 2) Not willing to participate in this study.

Design outcomes

Primary

MeasureTime frame
IL-2 Elispot;T cell killing ability;

Secondary

MeasureTime frame
Molecular indicators;

Countries

China

Contacts

Public ContactYu Yao

Huashan Hospital, Fudan University

1272087893@qq.com+86 183 1708 0153

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026