Cardiovascular response when intubated
Conditions
Interventions
Control group:Dexmedetomidine is not given before anesthesia induces endotracheal intubation
Dextmedetomidine Group1:Before anesthesia induction, dexmedetomidine 0.6ug/kg was given for 10min
Dextmedetomidine Group2:The patient was injected with a loading dose of 0.6 ug/kg dexmedetomidine pump for 10 minutes, rested for 20 minutes, and then induced endotracheal intubation under general ane
Sponsors
Hainan General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients undergoing elective double-lumen endotracheal tube intubation under general anesthesia and thoracic surgery, ASA grade I~III, age = 65 years old, = 85 years old. Body mass index (BMI) < 30 kg/m2
Exclusion criteria
Exclusion criteria: Known allergy to anesthetic drugs; history of sedative drug abuse and recent opioid use; hypertensive patients with poorly controlled blood pressure (basal blood pressure measured three times in a row after admission to the preoperative preparation room =160mmHg); tachycardia (HR> 100 beats per minute); Hepatic and renal insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patients with positive and negative reactions immediately after endotracheal intubation and within 5 minutes after intubation.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of cases of hypotension (SBP <90 mmHg) within 5 minutes of anesthesia induction and endotracheal intubation;Number of cases of bradycardia (heart rate = 50beats per minute) within 5 minutes of anesthesia induction and endotracheal intubation;Number of cases in which anesthesia induction, tracheal intubation, adverse hemodynamic time within 5 minutes required vasoactive drug rescue; | — |
Countries
China
Contacts
Public ContactWangZhihua
Hainan General Hospital
Outcome results
None listed