Hypertension complicated with mild cognitive impairment
Conditions
Interventions
acupuncture group:Acupoints: Baihui, Shenting, Neiguan, Ashansanli, Fenglong, Taichong
Acupoint localization: refer to the national standard of the People's Republic of China "Acupoint Name and Locali
Sponsors
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Eligible participants should meet the following requirements: (1) Meet the diagnostic criteria of hypertension; (2) Meet the diagnostic criteria of MCI, ? Mini-Mental State Examination (MMSE)=21 points and<27 points; ?Montreal Cognitive Assessment Scale(MoCA) =18 points and < 26 points; ?Activity of daily living scale(ADL) <22 points, and no more than one item in the single score may be =3 points; (3) Age 40-75 years old, right-handed, male or female; (4) Primary school education (6 years) or above, able to correctly understand and complete the scale; (5) no acupuncture treatment has been received within 3 months; (6) Voluntarily cooperate and sign informed consent;
Exclusion criteria
Exclusion criteria: Participants meeting any of the following criteria will be excluded: (1) Individuals who have undergone treatments potentially interfering with cognitive functions, such as the use of cognition-impacting medications (e.g., Donepezil, Memantine, Rivastigmine); (2). Individuals diagnosed with neurological or chronic conditions, including systemic diseases (e.g., anemia, tumors, metabolic disorders) that could impair cognitive functions; (3) Presence of infection or focal injury, as indicated by brain MRI, multiple infarcts, or cerebral white matter lesions in critical memory areas (Fazekas Rating >3); (4) Individuals with secondary hypertension, refractory hypertension, or hypertension accompanied by clinical syndromes and target organ damage; (5)Individuals experiencing aphasia, hearing impairment, muscle strength functional impairment below grade 3, severe visual impairment, or myopia exceeding 300, rendering them unable to cooperate with the test; (6)Patients with coexisting diabetes, hyperlipidemia, or a body mass index (BMI) 35); (8) Individuals with hemorrhagic conditions, bleeding tendencies, infectious skin diseases, or skin injuries; (9) Individuals with severe drug dependence, smoking, or alcoholism; (10) Women who are menstruating, pregnant, planning pregnancy or breastfeeding; (11)Individuals who have received acupuncture treatment or participated in other clinical trials within the past 3 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination;Blood pressure condition;verbal fluency test, VFT;the shape trail test, STT;Auditory Verbal Learning Test;Activity of daily living, ADL;Hamilton Anxiety Scale;Pittsburgh Sleep Quality Index;mean velocity (Vm);resistance index (RI);pulse index (PI);Aß-42;BDNF;tau; | — |
Countries
China
Contacts
Public ContactLili Zhang
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed