None
Conditions
Interventions
Propofol Group:Continuous intravenous infusion of propofol 4-12mg · kg-1 · h-1 and remifentanil 0.2-0.3 µg · kg-1 · min-1 for intraoperative anesthesia maintenance
Propofol-remimazolam Group:Continuous intravenous infusion of remimazolam 0.3mg · kg-1 · h-1+propofol 2-4mg · kg-1 · h-1 and remifentanil 0.2-0.3 µg · kg-1 · min-1 for intraoperative anesthesia mainte
Sponsors
Anesthesiology Department of Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patient informed consent; Plan to undergo laparoscopic surgery on a scheduled date; Expected surgical duration = 1 hour; American Society of Anesthesiologists (ASA classification) grades I-III; 65 years old<age<80 years old; Body mass index (BMI) 18-28kg/m2
Exclusion criteria
Exclusion criteria: Severe heart disease (NYHA heart function grading>level 3), severe renal insufficiency (blood creatinine>1.8mg/dL (159.1) µmol/L or receiving renal replacement therapy, severe liver dysfunction (modified Child Pugh grading to C grade); Individuals with a history of allergies to the anesthetic drugs involved in this study are known; Preoperative sleep disorders with a Pittsburgh sleep quality index (PSQI) score of = 7; Individuals who rely on sedatives, antidepressants, and alcoholics; Having mental illness or cognitive impairment, inability to cooperate and poor compliance; Patients with other contraindications to anesthesia or surgery; Refusing to sign informed consent form; Participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Awakening time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative PSQI score;Hemodynamic indicators during anesthesia;MOAA/S score during awakening period;Richmond Agitation and Sedation Scale during awakening period;VAS score at postoperative time points; | — |
Countries
China
Contacts
Public ContactLulong Bo
Shanghai Changhai Hospital
Outcome results
None listed