postoperative delirium
Conditions
Interventions
dexmetomidine group :Dexmetomidine was pumped for preemptive analgesia
oxycodone+dexmetomidine group :Oxycodone+dexmetomidine was pumped for preemptive analgesia
oxycodone group:Oxycodone was pumped for preemptive analgesia
Sponsors
Binzhou Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing laparoscopic surgery are aged 18 to 65 years.; 2. ASA I-III level; 3. BMI 18-35 kg/m^2; 4. Preoperative mini-mental state examination ( MMSE ) > 26 ; 5. Heart, lung, liver, and kidney functions have no obvious abnormalities; 6. Get informed consent
Exclusion criteria
Exclusion criteria: 1. education level < 9 years; 2. Patients with central nervous system disease or mental illness or have recently taken sedatives, antidepressants, a history of alcoholism, a history of drug dependence or long-term treatment with any sleep medication in the past 6 months, patients with a history of dementia and delirium; 3. Hearing or visual impairment cannot complete the test score. 4. Individuals with severe impairment of heart, lung, liver, kidney, or other organ functions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence rate of delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuron-specific enolase;plasma melatonin level;Cortisol concentration; | — |
Countries
China
Contacts
Public ContactChao Sun
Binzhou Medical University Affiliated Hospital
Outcome results
None listed