Depression
Conditions
Interventions
Case series (Adolescent depression patients receiving electroconvulsive therapy):None
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age 12-18 years. 2. Right-handed. 3. Diagnosed with major depression disorder (MDD) based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, (DSM-5), diagnosed by at least one deputy director of psychiatry or above physician. 4. 24-item Hamilton Rating Scale for Depression (HAMD-24) score =35, indicating severe depression. 5. This depressive episode may have self injurious suicidal behavior, or the Beck Suicide Intention Inventory (BSI-CV) suggests suicidal ideation. 6. Patients who have failed first-line treatment (such as fluoxetine, sertraline monotherapy, or combination cognitive-behavioral therapy). 7. Capable of comprehending and completing the study assessments. 8. Written informed consent provided by patients and/or their legal guardians.
Exclusion criteria
Exclusion criteria: 1. Presence of severe systemic diseases, including but not limited to severe liver, kidney, respiratory, cardiovascular, endocrine diseases, hematologic disorders, or neoplastic diseases. 2. Diagnosed with schizophrenia or any other primary psychotic disorders, bipolar disorder, dementia, substance dependence, or drug abuse according to DSM-V. 3. Significant neurological diseases that can affect cognitive function (such as autoimmune encephalitis, epilepsy). 4. Undergone electroconvulsive therapy (ECT) in the six months prior to the current hospitalization. 5. Known allergies or contraindications to concomitant drugs used in ECT. 6. Receiving repetitive transcranial magnetic stimulation (rTMS) or other neuromodulation treatments. 7. Participation in another clinical trial simultaneously.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cambridge Neuropsychological Test Automated Battery-Spatial Recognition Memory;Cambridge Neuropsychological Test Automated Battery-Spatial Working Memory;Cambridge Neuropsychological Test Automated Battery-Rapid Visual Information Processing;Cambridge Neuropsychological Test Automated Battery-Verbal Recognition Memory; | — |
Secondary
| Measure | Time frame |
|---|---|
| 24-item Hamilton Rating Scale for Depression ;Self-rated Depression Scale;Beck scale for suicide ideation - Chinese vision (BSI - CV); | — |
Countries
China
Contacts
Public ContactLuo Qinghua
Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed