depression
Conditions
Interventions
treatment group:Take Jiawei xiaoyao pills twice a day, 6g a time.
control group:Take Sertraline tablets one or twice a day, 50mg-200mg a time.
Sponsors
The people’s hospital of Danzhai
Eligibility
Sex/Gender
All
Age
12 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the DSM-V or ICD-10 diagnostic criteria for depression; 2. Patients with mild to moderate depression aged 12-75 years; 3. Patients with mild to moderate depression, Hamilton Depression Scale (24 items) score 35 points =HAMD-24=20 points; Montgomery Depression Rating Scale score 30 points =MADRS score =12 points; 4. Patients who have not used any Chinese medicine (including mind-soothing Chinese patent medicine and decoction) or Western medicine (Prozac, Lysopol, Bolaxin, etc.) for depression treatment in the past 1 week, or have taken the above drugs within a short period (3-5 days), and have stopped using them for more than 7 days; 5. Subjects who are willing to receive treatment for 42 days should give informed consent and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with suicidal depression, i.e., the third item score of Hamilton Depression Scale =2 points; 2. Currently suffering from other mental diseases other than depression, as well as external environmental interference factors or craniocerebral trauma caused; 3. Pregnant or lactating women; 4. People with a history of drug allergy; 5. Under the age of 12 or over the age of 75; 6. Patients with severe primary diseases of cardiovascular, lung, liver, kidney and hematopoietic system and severe organic brain diseases and mental disorders; 7. Alcohol and/or psychoactive substance, drug abusers and dependent persons (including sleeping pills); 8. Those who do not meet the inclusion criteria, do not use drugs according to regulations, cannot judge the efficacy or incomplete data affect the efficacy and safety judgment; 9. Those who cannot understand the content of the scale due to consciousness, language barriers, and insufficient intellectual and cultural level; 10. During the washout period (7 days), the patient's depressive symptoms returned to a healthy state, that is, the Hamilton Depression Scale score =20 after the washout period; 11. Patients who have had the disease for more than 2 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-24; | — |
Secondary
| Measure | Time frame |
|---|---|
| BDNF of serum;MADRS;QIDS-SR16;PHQ-9;Traditional Chinese Medicine Constitution Classification Scoring Scale; | — |
Countries
China
Contacts
Public ContactLong Wenkai
The people’s hospital of Danzhai
Outcome results
None listed