intraoperative hemodynamic
Conditions
Interventions
Rimazolam sedation group (Group R):In group R, rimazolam 0.1 mg/kg was given after plane fixation, followed by 5 µg/kg/min continuous pumping until the BIS dropped to 75, then the infusion rate was gr
Sponsors
Central Hospital Of Dalian University of Technology(Dalian Municipal Central Hospital)
Eligibility
Sex/Gender
All
Age
60 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. All sexes, aged > 60 years, ASA Class I-III; 2. Patients undergoing elective lower limb orthopaedic surgery; 3. Patients who have signed the informed consent and subject declaration.
Exclusion criteria
Exclusion criteria: Patients or family members who refuse to participate in the experiment; contraindications for combined spinal-epidural anesthesia (i.e., coagulopathy, infection at the puncture site, and refusal of combined spinal-epidural anesthesia); history of brain trauma or brain surgery; concurrent severe anemia, history of psychotropic drug or alcohol abuse; concurrent severe cardiac insufficiency (left ventricular ejection fraction EF < 30%) or bradycardia (heart rate < 60 beats per minute); significant impairment of hearing or vision, inability to communicate and cooperate (coma, dementia, language dysfunction); patients with malignant tumors; allergies to anesthetic drugs; patients or family members with poor compliance; those who change the original treatment plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of mean arterial pressure (MAP);Changes of heart rate (HR);Incidence of cardiovascular adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of Bispectral index value(BIS);Consumption of atropine;Postoperative delirium;Visual Analogue Scale (VAS) score;Consumption of norepinephrine; | — |
Countries
China
Contacts
Public ContactCongjie Bi
Central Hospital Of Dalian University of Technology(Dalian Municipal Central Hospital)
Outcome results
None listed