bilirubin encephalopathy
Conditions
Interventions
Gold Standard:Patients with hyperbilirubinemia appear clinical symptoms of nerve damage (the initial symptoms are feeding difficulties, high-pitched cries, high body temperature, lethargy. The conditi
Index test:1. The indexes included: total bilirubin, direct bilirubin, indirect bilirubin, transcutaneous bilirubin, albumin, total protein, hemoglobin, platelet count, time of bilirubin decrease, seq
Sponsors
Guangzhou Women and Children's Medical Center,Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 0.5 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1 )serum total bilirubin concentration > 205 µmol/L (12 mg/dl) , premature infants > 256 µmol/L (15 mg/dl) . (2) newborns with gestational age =35 weeks. (3) brain MRI was performed within 10 days after admission. (4) the clinical diagnosis was bilirubin encephalopathy.
Exclusion criteria
Exclusion criteria: (1)children with intrauterine infection or hypoglycemia; (2) children with intracranial hemorrhage or congenital brain malformation; (3) those accompanied with neonatal asphyxia; (4)patients with congenital nervous system disorders or metabolic diseases; (5 )poor image quality, sequence incomplete image.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T1WI;T2WI;DWI;ADC;total bilirubin;indirect bilirubin;direct bilirubin;transcutaneous bilirubin;The time it takes for total bilirubin to drop to normal;sequela;Clinical diagnosis;Accuracy ;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| total protein;hematocrystallin;albumin;blood platelet count;gestational age;age of onset; weight;hospital stays;Clinical treatment methods;Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactShuyi Liu
Guangzhou Women and Children's Medical Center,Guangzhou Medical University
Outcome results
None listed