stroke
Conditions
Interventions
treatment group:Pairing frequency: 10Hz, stimulation for 2 seconds, rest for 5 seconds
A total of 1200 pulses of coordinated stimulation
Pairing interval: 25ms
Peripheral stimulation target: median nerve of affected limb
Stimulation intensity: the minimum intensity that can cause wrist movement
Central stimulation target: M1 of affected brain
Stimulation intensity: 100% rMT.
control group:the control group is to set the peripheral stimulation intensity of the PAS group to 0, and the rest are the same as the PAS group
Sponsors
Tongji University Affiliated Tongji Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with stroke by clinical evaluation and imaging results; (2) The first stroke occurred, and the course of disease was between 3 and 12 months; (3) Aged 45-80, male or female; (4) Brunnstorm 3-4; (5) Normal cognitive function (normal as assessed by the simple mental scale).
Exclusion criteria
Exclusion criteria: (1) There is a serious systemic disease and cannot tolerate rehabilitation treatment; (2) Diagnosed mental illness, major depression, epilepsy or related family history; (3) diabetes, uremia and other serious systemic diseases; (4) Patients with contraindications to transcranial magnetic stimulation and fMRI according to safety guidelines, such as metal or other electronic devices implanted in the body; (5) Application of corticoexcitatory drugs (such as anti-epileptic drugs, anti-anxiety and depression drugs, etc.) within 1 month; (6) During drug or alcohol withdrawal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Action Research Arm Test (ARAT); | — |
Secondary
| Measure | Time frame |
|---|---|
| Fugl-meyer assessment-upper limbs (FMA-UL);modified barthel Index (MBI);modified Tardieu scale (MTS);functional near-infrared spectroscopy(fNIRS);motor evoked potential (MEP);somatosensory evoked potential (SEP);cortical resting period (CSP); | — |
Countries
China
Contacts
Public ContactChen Yuhui
Tongji University Affiliated Tongji Hospital
Outcome results
None listed