Acute ischemic cerebrovascular disease
Conditions
Interventions
Intravenous thrombolysis group:Intravenous injection of rhTNK-tPA, 0.25mg/kg
Non-intravenous thrombolytic group:Aspirin 100mg qd orally
Sponsors
Suzhou Science and Technology City Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: ? Age: 18-85 years old ? The normal time (LWT) is finally known 4.5-24 hours; ? NIHSS score 3-5 points; ? Disabling stroke; Including: 1) complete hemianopsia (NIHSS problem 3=2); 2) Severe aphasia (NIHSS problem 9=2); 3) blindness or loss of sensation (NIHSS problem 11=1); 4) The muscle strength score of any limb is more than 2 points (NIHSS problem 5 or 6=2); (5) Head MRI DWI/FLAIR imaging suggests mismatch areas (DWI sequence shows high signal, FLAIR sequence does not correspond to high signal). ? Subject or guardian sign informed consent;
Exclusion criteria
Exclusion criteria: ? History of major head trauma or stroke in the past 3 months; (2) Large cerebral infarction (infarct area > 1/3 middle cerebral artery blood supply area); ? Intracranial hemorrhage (including parenchymal hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, subdural/extrinsic hematoma, etc.); ? In the past 1 week, the artery puncture in the part that is not easy to compress; (5) History of intracranial hemorrhage; ? Intracranial tumor, intracranial giant aneurysm; ? Intracranial or intraspinal surgery in the past 3 months; ? Major surgical operations in the past 2 weeks; ? Aortic arch dissection; ? Active visceral hemorrhage; Other planned surgical or interventional treatments; Being tested with an investigational drug or device; Women of childbearing age, pregnant women or breastfeeding women who refuse to take effective contraceptive measures despite negative pregnancy tests; 14 Participated in other clinical drug studies in the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of good 90-day outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day mRS 0-2 score ratio;The proportion of early neurological function improved by NHISS=2 points within 24 hours;Proportion of neurological deterioration within 72 hours (NIHSS score increase =4 points);EQ-5D score; | — |
Countries
China
Contacts
Public ContactLij Jingwei
Suzhou Science and Technology City Hospital
Outcome results
None listed