parkinson's disease
Conditions
Interventions
SMA-M1 paired transcranial magnetic stimulation group (paired stimulation group, namely treatment group) :The treatment group received SMA-M1 paired transcranial magnetic stimulation, 5 times a week f
SMA sham-M1 transcranial magnetic stimulation group (conventional treatment group, the control group):The control group received sham-stimulation of SMA and M1 transcranial magnetic stimulation. The s
Sponsors
ShanghaiTongji Hospital (Tongji Hospital of Tongji University)
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Diagnosis of Parkinson's disease with motor symptoms and stable medication treatment; (2) Hoehn-Yahr (H-Y) stage 1 to 4; (3) Age 50-80 years, both genders; (4) Normal cognitive function, able to cooperate with assessment and treatment; (5) Willing to sign written informed consent.
Exclusion criteria
Exclusion criteria: (1) Presence of metal implants within a 20cm range of the stimulation site, including DBS. (2) History of epilepsy or predisposing factors for seizures (such as very low rMT). (3) Currently taking medications or consuming foods that significantly affect the effects of magnetic stimulation (such as phenothiazines, amitriptyline, etc.). (4) Concurrent severe illnesses that may hinder completion of treatment. (5) Special populations such as pregnant or lactating women. (6) Patients with tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Parkinson's Disease Quality of Life Questionnaire (PDQ-39);electromyography;Functional Near Infrared Spectral Brain Imaging (fNIRS);Non-motor Symptom Scale (NMSS);Security Index; | — |
Countries
China
Contacts
Public ContactYuhui Chen
ShanghaiTongji Hospital (Tongji Hospital of Tongji University)
Outcome results
None listed