Laparoscopic cholecystectomy
Conditions
Interventions
Opioid-Free Group :Esketamine was used for analgesia.
Opioid-Based Group :Sufentanil and remifentanil were used for analgesia.
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) 18 to 65 years old; (2) ASA physical status I-II; (3) undergoing elective laparoscopic cholecystectomy; (4) willing to sign informed consent.
Exclusion criteria
Exclusion criteria: (1) allergy to related medication; (2) a history of surgery within the past 1 month; (3) patients with nervous system diseases or mental disorders; (4) unable to understand the Digital Rating Scale (NRS); (5) patients with untreated or poorly controlled hypertension (arterial hypertension, resting systolic/diastolic blood pressure > 180/100 mmHg); (6) patients with untreated or undertreated hyperthyroidism; (7) patients with unstable angina or myocardial infarction in the past 6 months; (8) high intraocular pressure (glaucoma) and penetrating ocular trauma, the intraocular pressure can not be increased.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical rating scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative blood pressure;Perioperative heart rate;Duration of surgery;Duration of extubation;Dosage of vasoactive agents;Postoperative nausea and vomiting;Postoperative delirium;Postoperative hypoxemia;The time of first request for analgesic after surgery;The first postoperative analgesic dosage was requested;Length of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactZhou, Ling
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed