Hepatocellular carcinoma
Conditions
Interventions
TACE group: Patients with advanced-stage liver cancer with Child-Pugh score =8 points and either irreparable or Performance Status (PS) score =2 points, who are not eligible for surgery.:The best supp
TACE+TKI+ICIs group: Patients with a Performance Status (PS) score of 0-1, Child-Pugh score =7, and inadequate response of residual lesions (residual single lesion within 5cm or multiple lesions with
TACE+RFA+TKI+ICIs group: Patients with a Performance Status (PS) score of 0-1, Child-Pugh score =7, and residual single lesion within 5cm or multiple lesions with the largest being within 3cm.:Provide
Sponsors
The First People's Hospital of Yibin
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Confirmed diagnosis of primary liver cancer by pathology or imaging, with Barcelona Clinic Liver Cancer (BCLC) stage B or above; 2) Child-Pugh score =7 points; 3) Performance Status (PS) score of 0-1; 4) Hematological examination: white blood cells =2.0×10^9/L, hemoglobin =80g/L, platelets =50×10^9/L; 5) Expected survival =12 weeks; 6) Signed informed consent form, age =18 years. (1, 5 cited from "Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 edition)")
Exclusion criteria
Exclusion criteria: 1) Combined with a second primary tumor; 2) Patients in pregnancy or lactation; 3) Tumor invasion of hollow visceral organs or bile duct obstruction; 4) Irreversible coagulation dysfunction; 5) Failure of important organ functions such as heart, lung, liver, and kidney; 6) Organ transplant recipients; 7) Patients with poorly controlled autoimmune diseases; 8) Allergic to any drugs used in this treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum lesion diameter.;Sum of the diameters of measurable target lesions.; | — |
Countries
China
Contacts
Public ContactChen Xiaochun
The First People's Hospital of Yibin
Outcome results
None listed