Anesthesia for patients undergoing ERCP surgery
Conditions
Interventions
Low-dose esketamine group:Anesthesia induction (esketamine 0.25 mg/kg + remimazolam 0.2 mg/kg) + anesthesia maintenance (esketamine 0.5 mg/kg/h + remimazolam 1 mg/kg/h)
High-dose esketamine group:Anesthesia induction (esketamine 0.4 mg/kg + remimazolam 0.2 mg/kg) + anesthesia maintenance (esketamine 0.5 mg/kg/h + remimazolam 1 mg/kg/h)
Propofol combined with remifentanil group:Anesthesia induction (propofol 1.5 mg/kg + remifentanil 1 ug/kg) + anesthesia maintenance (propofol 5 mg/kg/h + remifentanil 5 ug/kg/h)
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18~75 years old; (2)BMI:18~30(kg/m2); (3) ASA classification: I~III; (4) Patients who have been excluded from contraindication to surgery and intend to undergo ERCP; (5) Patients who intend to participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Hearing or vision impairment and inability to cooperate; (2) Allergy to the known drugs involved in the use or contraindication of use; (3) the presence of psychiatric diseases; (4) poorly controlled hypertension; (5) Those with severe coronary heart disease or heart failure and cardiac function is grade III~IV; (6) Combined with other systemic serious diseases: such as abnormal coagulation function, liver and kidney dysfunction, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypoxemia;Modified alertness/sedation score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypotension;Movement occurs;Degree of choking reaction; | — |
Countries
China
Contacts
Public ContactOu Wei
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed