infertility
Conditions
Interventions
Modified antagonist protocol (study group):A fixed regimen of GnRH-antagonist was used for all study participants. Daily subcutaneous injections of the GnRH antagonist are administered from day 5 of o
Conventional antagonist protocol (control group):Daily subcutaneous injections of the GnRH antagonist are administered from day 5 of ovarian stimulation. Patients completed their treatment cycle witho
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
21 Years to 37 Years
Inclusion criteria
Inclusion criteria: 1. Age 1.2ng/ml, antral follicle count (AFC) > 7; 3. First IVF/ICSI cycle; 4. 18.5kg/m2 = BMI 6 and < 20.
Exclusion criteria
Exclusion criteria: 1. Polycystic ovary syndrome, endometriosis, and patients were planning cycles of PGT. 2. Recurrent spontaneous abortion. 3. Uterine abnormalities (such as a uterine malformation, adenomyosis, intrauterine adhesion, or sub-mucous myoma). 4. Hydrosalpinx without ligation or resection surgery. 5. Chromosomal abnormalities. 6. Existence of factors that have a negative impact on the pregnancy outcome of fresh embryo transfer or not suitable for fresh embryos transfer, such as premature progesterone elevation, infection, bleeding, fever. 7. Patients who are at risk of OHSS, such as E2 = 5000pg/mL or number of growing follicles = 20, or patients developed any sign or symptoms of OHSS. 8. Untreated medical conditions that are contraindications to IVF procedures or pregnancy, such as uncontrolled hypertension, symptomatic heart disease, poorly controlled type 1 or type 2 diabetes, poor liver function, renal insufficiency, severe anemia, previous history of thrombosis, cerebrovascular disease. 9. Patients receiving sperm from testicular sperm extraction (TESE), testicular sperm aspiration (TESA), or micro TESE.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate per fresh cycle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum estradiol (E2) level on hCG day;Serum progesterone (P) level on hCG day;Premature LH surge rate;Early ovulation rate;Number of oocytes retrieved;Number of available embryos;Blastocyst formation rate;Good-quality embryo rate;Clinical pregnancy rate;Early miscarriage rate;Ongoing pregnancy rate;Fresh cycle embryo transfer cancellation rate; | — |
Countries
China
Contacts
Public ContactJin Lei
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed