postoperative nausea and vomiting
Conditions
Interventions
Penehyclidine hydrochloride group:Penehyclidine 0.25 mg is injected before anesthesia, and 0.25 mg penehyclidine is continuously infused 48 h after operation.
Control group:Normal saline 2.5 ml is injected before anesthesia and 2.5 ml normal saline is continuously infused within 48 h after operation.
Sponsors
Henan Provincial Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Age : 18 years old = age < 65 years old; 2. body mass index : 18 kg / m2 = BMI < 30 kg / m2; 3.ASA grade : I ~ III grade; 4.Surgical type : It is planned to receive thoracoscopic radical resection of lung cancer, and postoperative analgesia pump is needed after operation.
Exclusion criteria
Exclusion criteria: 1. Existence of glaucoma; 2. Allergic to penehyclidine, atropine, scopolamine or other anticholinergic drugs; 3. Acute or chronic nausea or vomiting, or preoperative gastrointestinal motility disorders; 4. History of schizophrenia, Parkinson 's disease, severe dementia or language disorder; 5.Severe liver dysfunction ( Child-Pugh C ), severe renal dysfunction; 6. ASA grade = IV; 7. Patients involved in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total incidence of PONV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Partial incidence and severity of PONV;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactZhou Junhui
Henan Provincial Chest Hospital
Outcome results
None listed