idiopathic membranous nephropathy
Conditions
Interventions
Sponsors
The First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: a)Age:18-70 years old; b)Pathologically diagnosed as idiopathic membranous nephropathy; c)Persistent of 24-hour urinary protein is more than 1g and less than 3.5g; d)eGFR>60 mL/min/1.73m2; e)Plan to give the patient supportive treatment, including angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin-receptor blockers (ARBs); f)Agree to participate in this project and sign an informed consent form.
Exclusion criteria
Exclusion criteria: a)Patients have secondary membranous nephropathy from various causes (e.g., hepatitis B/C virus infection, lupus, malignancy, rheumatoid arthritis, drug and heavy metal poisoning); b)The patient had other co-existing kidney disease; c)The expected survival time of severe cardio-vascular and cerebrovascular diseases, pulmonary insufficiency, malignant tumors and other diseases is less than 3 months, combined with other autoimmune diseases, diabetes; d)Gastrointestinal active bleeding; e)Acute and chronic gastroenteritis; f)Have previously received or are undergoing FMT treatment; g)Received antibiotics for 3 consecutive days or more within 1 month before enrollment; h) Probiotic supplement treatment 1 month before enrollment; i)Infect HIV; j)Mental illness or mental retardation; k) Women who have a pregnancy plan or are breastfeeding within 18 months; l)Medical history of alcohol or drug abuse; m)Other situations that the researchers think are not suitable for participation in this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment period of 6 months: Clinical remission (partial remission and complete remission) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment period of 6 months: serum creatinine doubled from baseline; eGFR =30% lower than baseline; develop into ESRD ;Follow-up for 6 months after the end of the treatment period: clinical response (partial remission and complete remission); creatinine levels doubled from baseline; eGFR =30% lower than baseline; developed intothe ESRD; | — |
Countries
China
Contacts
Public ContactShiren Sun
The First Affiliated Hospital of the Air Force Medical University
Outcome results
None listed