Chronic occlusion of internal carotid artery
Conditions
Interventions
Interventional recanalization group:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-90 years; and 2) 100% stenosis of the internal carotid artery lumen in cross-sectional view on CT angiography or magnetic resonance angiography, confirmed by diagnostic angiography (DSA); 3) Occlusion time greater than 4 weeks from discovery to present (confirmed by imaging or inferred from responsible event); 4) CTP or MRI ASL suggesting hypoperfusion in the internal carotid artery region on the side of the occlusion; 5) Presence of any of the following clinical symptoms: (1) Presence of ischemic cerebral infarction or TIA; (2) Recurrent dizziness, malaise, and unresponsiveness considered to be due to hypoperfusion; (3) Presence of transient dark haze symptoms; and (4) Mild cognitive dysfunction (18<Moca<26) 6) The patient is willing to visit the participating study unit or designated physician for regular follow-up visits as specified in the trial; 7) Patients and family members are able to make telephone follow-up visits; 8) The patient understands the significance and purpose of the trial, voluntarily participates in the trial and signs a consent form.
Exclusion criteria
Exclusion criteria: 1) mRS score >2 2) Combination of severe posterior circulation intracranial artery stenosis; 3) Pregnant or lactating women; 4) Severe dementia (Moca 1.5, and coagulation factor abnormalities leading to increased risk of bleeding; 9) Severe hepatic impairment (ALT or AST > 3 times the upper limit of normal, cirrhosis), creatinine > 3.0 (unless the patient is on dialysis); those with combined cardiac and respiratory failure; 10) Explicit allergy or contraindication to aspirin, clopidogrel, heparin, stent component nickel-titanium alloy, and local or general anesthetics; 11) A history of fatal allergy to contrast media; if allergic but non-fatal, it can be effectively prevented by careful preoperative evaluation by a specialist; 12) those with a life expectancy of no more than 3 years; and those with combined intracranial or extracranial malignancies; and those with combined malignant tumors; 13) who have been enrolled in other studies that may conflict with the current study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular recanalization rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 365-day and 730-day stroke recurrence rate;365-day and 730-day reocclusion rate after successful operation ;90-day, 365-day and 730-day cognitive tests ;90-day, 365-day and 730-day mood assessments;90-day, 365-day and 730-day activity of daily living tests ;Intraoperative and perioperative complication rate; | — |
Countries
China
Contacts
Public ContactQuanbin Zhang
Shanghai Tenth People's Hospital
Outcome results
None listed