Autoimmune encephalitis
Conditions
Interventions
Autoimmune encephalitis group:No interventions
Non-inflammatory, non-immune control group:No interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
14 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) At least meet the diagnostic criteria of "possible autoimmune encephalitis" proposed by Graus et al. in The Lancet in 2016. (2) Antibody-positive patients are defined as those with unambiguous detection of autoimmune encephalitis antibodies in cerebrospinal fluid and/or serum. (3) Patients with negative antibodies but suspected autoimmune encephalitis should meet the diagnostic criteria of "autoantibody-negative but probable autoimmune encephalitis" proposed by Graus et al. in The Lancet in 2016. (4) Acute phase, onset whthin 6 months.
Exclusion criteria
Exclusion criteria: (1) Patients who lack key clinical data or adequate amounts of biological specimens; (2) Patients with a diagnosis of human immunodeficiency virus (HIV) infection, brain abscess, viral disease, cerebral malaria, brain tumor, or non-communicable central nervous system disease such as acute demyelinating encephalomyelitis (ADEM); (3) Patients with central nervous system infection with bacteria, fungi, parasites or Mycobacterium tuberculosis (TB); (4) Patients with encephalopathy secondary to sepsis or systemic inflammatory response syndrome; (5) Subjects with history of other autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| CASE score;Montreal Cognitive Assessment; | — |
Countries
China
Contacts
Public ContactZhen Hong
West China Hospital, Sichuan University
Outcome results
None listed