Gastric cancer, colon cancer and rectal cancer
Conditions
Interventions
Esketamine anesthesia scheme group (K1 group):Anesthesia induction in Esketamine anesthesia scheme group (K1 group): Esketamine 0.25mg/kg iv, and anesthesia maintenance: Esketamine 0.2mg/kg/h was cont
Esketamine anesthesia scheme group (K2 group):Anesthesia induction in Esketamine anesthesia scheme group (K2 group): Esketamine 0.25mg/kg iv, and anesthesia maintenance was routine medication, and Esk
Standard opioid-containing anesthesia regimen group (group S):The standard opioid-containing anesthesia scheme group (group S) was given 0.25 mg/kg iv saline in addition to routine medication, and ane
Sponsors
Xing 'an League People's Hospital
Eligibility
Sex/Gender
All
Age
32 Years to 76 Years
Inclusion criteria
Inclusion criteria: 1. Age 32-76 years old 2. ASA ?-? 3. Undergo laparoscopic gastrointestinal surgery 4. Sign informed consent form
Exclusion criteria
Exclusion criteria: 1. Pregnant women 2. Asa level 3 or above 3. Emergency operation 4. Adults protected by law (under judicial protection, guardianship or supervision), persons deprived of their liberty. 5. Atrioventricular block, sinoatrial node block or intraventricular block 6. Sinus bradycardia (basal heart rate less than 60 beats /min) 7. Preoperative hypotension (systolic blood pressure below 100mmHg) 8. Preoperative complications included otolith, Meniere's syndrome and vertebral artery stenosis. 9.Ccerebrovascular disease 10. Contraindications of ?NSAIDs drugs 11. Allergic to narcotic drugs 12. Those who converted to laparotomy were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mechanical pain threshold of 5cm beside the surgical incision and the medial forearm was recorded before and 2, 6, 24 and 48 h after operation.;Visual analogue scale (VAS) score;The number of self-controlled analgesic compressions and the cumulative amount of opioids used 48 hours after operation;Postoperative adverse reactions were recorded, including nausea, vomiting, dizziness, delirium or disorientation.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of vascular complications in operation center (incidence rate of arrhythmia, application rate of antihypertensive drugs, application rate of antihypertensive drugs);Intraoperative sufentanil dosage;;Basic information during operation (blood pressure, heart rate, body temperature, BIS);Dosage of vasoactive drugs during operation (ephedrine, phenylephrine, atropine, urapidil, esmolol, etc.);Intraoperative infusion volume, bleeding volume and urine volume;Intraoperative complications (arrhythmia, myocardial infarction, cardiac arrest, hypoxemia, allergy, intraoperative awareness, etc.);Time from drug withdrawal to tracheal intubation removal;Time from extubation to Aldrete is more than 9 minutes.;Pain at 2h, 6h, 24h, 48h after tracheal intubation (mechanical pain threshold of 5cm beside the surgical incision and inside the forearm, VAS score);The dosage of opioids 48 hours after operation.;Incidence rate of postoperative cardiovascular complications;Postoperative hospitalization days; | — |
Countries
China
Contacts
Public ContactMa Yuhua
Xing 'an League People's Hospital
Outcome results
None listed