membranous nephropathy
Conditions
Interventions
Obinutuzumab group:Obinutuzumab
Sponsors
The Second People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age =18 years ; 2.Primary membranous nephropathy diagnosed by renal biopsy; 3.Resist to Rituximab treatment : no remission of urinary protein after the use of RTX ( 1g / time, 2 times / course , interval of 2 weeks ) after 9 months ; or ARA positive ; 4.No hormone or other immunosuppressive agents were used within 12 months; 5.Estimated glomerular filtration rate ( GFR ) = 30 mL / min / 1.73 m2; 6. Sign informed consent before medication.
Exclusion criteria
Exclusion criteria: 1.There are secondary causes of membranous nephropathy ( including special infections such as active hepatitis, active tuberculosis, rheumatic immune system diseases such as SLE, malignant tumor or MN caused by drug factors ) ; 2.Serum creatinine > 2.0 mg / dL or estimated GFR < 30 mL / min / 1.73 m2 ; 3.There are complications of nephrotic syndrome such as active infection, acute kidney injury and thromboembolism; 4.Pregnancy status or plan to conceive or lactation women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrence rate;Renal prognosis; | — |
Countries
China
Contacts
Public ContactLiu Yang
The First Affiliated Hospital of Shenzhen University (the Second People's Hospital of Shenzhen)
Outcome results
None listed