anxiety depressive disorders
Conditions
Interventions
RIC Group:Training methods for remote ischemic preconditioning:
(1) Usage: For external use, the sleeves are fixed on both upper arms (consistent with the blood pressure measurement position)
(2) Treatment pressure: 200mmHg
(3) Treatment mode: twice a day, with 5 minutes of pressure, 5 minutes of rest, and 5 cycles per treatment operation.
sham-RIC Group:Training methods for remote ischemic preconditioning:
(1) Usage: For external use, the sleeves are fixed on both upper arms (consistent with the blood pressure measurement position)
(2) Treatment pressure: 60mmHg
Sponsors
Shanghai Yangpu District Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age range from 18 to 65 years old; 2) Having a junior high school or above education level; 3) According to the diagnostic criteria of the Diagnostic and Statistical Manual for Mental Disorders, 5th edition (DSM-5), anxiety related depression (depression with anxiety and pain) is defined as anxiety and pain if at least 2 of the following symptoms are present during most days of a major depressive episode or persistent depressive disorder (adverse mood): feeling excited or tense; Feeling abnormally restless and restless; Difficulty concentrating due to worry; Fear that something terrible may happen; I feel like I may lose self-control. 4) The Quick Self Rating Depression Symptom Scale (QIDS-SR16) scores = 16; 5) Willing to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: ? Diagnosis of previous or current bipolar disorder through DSM-5 clinical interview (SCID-5); ? Currently suffering from serious physical illness; ? Individuals with intellectual disabilities (based on a comprehensive assessment of medical history, interviews, work, culture, etc.); ? Current serious suicide risk (doctor's judgment or QIDS-SR16 suicide score = 3 points); ? The patient's previous treatment with escitalopram was ineffective or intolerable; ? Received or planned to receive ECT, rTMS, or invalid in the past 6 months; ? Serious or active physical diseases that may interfere with research and treatment, including but not limited to: those who use thrombolytic therapy; Individuals with progressive worsening of neurological conditions; Intracranial infection, intracranial hemorrhage, intracranial tumor, or any other brain disease that is not suitable for enrollment; Suffering from uncontrollable severe hypertension (after medication treatment, systolic blood pressure>180mmHg or diastolic blood pressure>110mmHg); The laboratory test indicators are unqualified, with aspartate aminotransferase or alanine aminotransferase three times higher than the normal upper limit, creatinine clearance rate265umol/l (>3.0mg/dl), and platelets<100 × 109/L; Individuals with severe hematological disorders, severe coagulation function, retinal or visceral bleeding; Individuals who have undergone or are expected to undergo major surgeries during the research period (including stent implantation, angioplasty, or other related medical device treatments); Taboos for adaptation to distant ischemia, such as severe soft tissue damage, fractures or vascular injuries in the upper limb, and peripheral vascular lesions in the distal upper limb; Any systemic diseases that are not suitable for enrollment. ? Other situations that the researchers believe are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QIDS-SR16;Effective rate;Emotional state, quality of life, biological rhythm; | — |
Countries
china
Contacts
Public ContactJun wang
Shanghai Yangpu District Mental Health Center
Outcome results
None listed