Cerebral small vessel disease
Conditions
Interventions
Test group:Resolving Phlegm and Dispelling Blood Stasis formula (Semen xia 10g, Atractylodes macrocephala 10g, Tianma 10g, Poria)12g, Radix Codonopsis pilosulae 15g, Pericarpium Citri Reticulatae 12g,
Control group:Basic treatment (appropriate symptomatic treatment for blood pressure control, blood glucose, lipid lowering and anti-platelet aggregation)
Sponsors
Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Clinical manifestations related to CSVD, motor impairment, cognitive impairment, autonomic dysfunction symptoms, fulfillment of one of them is sufficient. (2) Cranial MRI examination with clear CSVD imaging manifestations, such as recent subcortical small infarcts, high signal in the white matter of the brain, cerebral microhemorrhage and so on. (3) Age =50 years, =80 years; (4) Voluntary participation in the trial and signing the informed consent form.
Exclusion criteria
Exclusion criteria: (1) The presence of tremor, claustrophobia, etc. leads to poor MRI image quality and affects the CSVD evaluation; (2) History of traumatic brain injury, serious psychiatric disorders, serious heart diseases, malignant tumors, etc. (3) History of multiple sclerosis, craniocerebral tumor, central nervous system demyelination, severe stenosis of intracranial and extracranial arteries, and so on. (4) Serious hearing, speaking, reading and writing disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tinetti Performance Oriented Mobility Assessment, POMA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment, MoCA;Autonomic Symptom Profile, ASP; | — |
Countries
China
Contacts
Public ContactZHANG HUI
Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine
Outcome results
None listed